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PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells.
Zhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris RC, Li S, Coffey RJ, Sun L, Wu D, Chen XZ, Breyer MD, Zhao ZJ, McKanna JA, Wu G. Zhang MZ, et al. Among authors: kim i. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2311-6. doi: 10.1073/pnas.0400073101. Proc Natl Acad Sci U S A. 2004. PMID: 14983006 Free PMC article.
Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells.
Mai W, Chen D, Ding T, Kim I, Park S, Cho SY, Chu JS, Liang D, Wang N, Wu D, Li S, Zhao P, Zent R, Wu G. Mai W, et al. Among authors: kim i. Mol Biol Cell. 2005 Sep;16(9):4398-409. doi: 10.1091/mbc.e04-11-1019. Epub 2005 Jun 22. Mol Biol Cell. 2005. PMID: 15975909 Free PMC article.
Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin.
Kim I, Li C, Liang D, Chen XZ, Coffy RJ, Ma J, Zhao P, Wu G. Kim I, et al. J Biol Chem. 2008 Nov 14;283(46):31559-66. doi: 10.1074/jbc.M805452200. Epub 2008 Sep 9. J Biol Chem. 2008. PMID: 18782757 Free PMC article.
Our recent study reported that a deficiency in FPC increases the severity of cystic disease in Pkd2 mutants and down-regulates PC2 in vivo, but the precise molecular mechanism of these effects is unknown (Kim, I., Fu, Y., Hui, K., Moeckel, G., Mai, W., Li, C., Liang …
Our recent study reported that a deficiency in FPC increases the severity of cystic disease in Pkd2 mutants and down-regulates PC2 in vivo, …
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway.
Liu B, Staron M, Hong F, Wu BX, Sun S, Morales C, Crosson CE, Tomlinson S, Kim I, Wu D, Li Z. Liu B, et al. Among authors: kim i. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6877-82. doi: 10.1073/pnas.1302933110. Epub 2013 Apr 9. Proc Natl Acad Sci U S A. 2013. PMID: 23572575 Free PMC article.
Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass.
Choi S, Kang JG, Tran YTH, Jeong SH, Park KY, Shin H, Kim YH, Park M, Nahmgoong H, Seol T, Jeon H, Kim Y, Park S, Kim HJ, Kim MS, Li X, Bou Sleiman M, Lee E, Choi J, Eisenbarth D, Lee SH, Cho S, Moore DD, Auwerx J, Kim IY, Kim JB, Park JE, Lim DS, Suh JM. Choi S, et al. Among authors: kim iy. Nat Metab. 2024 May;6(5):847-860. doi: 10.1038/s42255-024-01045-4. Epub 2024 May 29. Nat Metab. 2024. PMID: 38811804
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