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Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin.
Veitch DP, Nokelainen P, McGowan KA, Nguyen TT, Nguyen NE, Stephenson R, Pappano WN, Keene DR, Spong SM, Greenspan DS, Findell PR, Marinkovich MP. Veitch DP, et al. Among authors: spong sm. J Biol Chem. 2003 May 2;278(18):15661-8. doi: 10.1074/jbc.M210588200. Epub 2002 Dec 7. J Biol Chem. 2003. PMID: 12473650 Free article.
CTGF is a therapeutic target for metastatic melanoma.
Finger EC, Cheng CF, Williams TR, Rankin EB, Bedogni B, Tachiki L, Spong S, Giaccia AJ, Powell MB. Finger EC, et al. Among authors: spong s. Oncogene. 2014 Feb 27;33(9):1093-100. doi: 10.1038/onc.2013.47. Epub 2013 Feb 25. Oncogene. 2014. PMID: 23435419 Free PMC article.
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