Co(II) and Cd(II) substitute for Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating a variety of potential mechanisms of toxicity.
Kopera E, Schwerdtle T, Hartwig A, Bal W.
Kopera E, et al. Among authors: schwerdtle t.
Chem Res Toxicol. 2004 Nov;17(11):1452-8. doi: 10.1021/tx049842s.
Chem Res Toxicol. 2004.
PMID: 15540943
To study the possible molecular mechanisms of XPA inhibition, we previously investigated Zn(II) and Ni(II) interactions with the synthetic 37 amino acid peptide (XPAzf), AcDYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKam, representing the XPA zinc finger sequence (Bal, W., Schwerdtle …
To study the possible molecular mechanisms of XPA inhibition, we previously investigated Zn(II) and Ni(II) interactions with the synthetic 3 …