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Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).
Pruitt JR, Pinto DJ, Galemmo RA Jr, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, Luettgen JM, Knabb RM, Lam PY, Wexler RR. Pruitt JR, et al. Among authors: drummond s. J Med Chem. 2003 Dec 4;46(25):5298-315. doi: 10.1021/jm030212h. J Med Chem. 2003. PMID: 14640539
Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues.
Qiao JX, Cheng X, Smallheer JM, Galemmo RA, Drummond S, Pinto DJ, Cheney DL, He K, Wong PC, Luettgen JM, Knabb RM, Wexler RR, Lam PY. Qiao JX, et al. Among authors: drummond s. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1432-7. doi: 10.1016/j.bmcl.2006.11.071. Epub 2006 Dec 1. Bioorg Med Chem Lett. 2007. PMID: 17174550
Novel piperidine sigma receptor ligands as potential antipsychotic drugs.
Gilligan PJ, Cain GA, Christos TE, Cook L, Drummond S, Johnson AL, Kergaye AA, McElroy JF, Rohrbach KW, Schmidt WK, et al. Gilligan PJ, et al. Among authors: drummond s. J Med Chem. 1992 Nov 13;35(23):4344-61. doi: 10.1021/jm00101a012. J Med Chem. 1992. PMID: 1360026
368 results