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Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
L'Episcopo F, Tirolo C, Caniglia S, Testa N, Serra PA, Impagnatiello F, Morale MC, Marchetti B. L'Episcopo F, et al. Among authors: morale mc. J Neuroinflammation. 2010 Nov 23;7:83. doi: 10.1186/1742-2094-7-83. J Neuroinflammation. 2010. PMID: 21092260 Free PMC article.
Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1).
Gennuso F, Fernetti C, Tirolo C, Testa N, L'Episcopo F, Caniglia S, Morale MC, Ostrow JD, Pascolo L, Tiribelli C, Marchetti B. Gennuso F, et al. Among authors: morale mc. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2470-5. doi: 10.1073/pnas.0308452100. Proc Natl Acad Sci U S A. 2004. PMID: 14983033 Free PMC article.
Glia as a turning point in the therapeutic strategy of Parkinson's disease.
L' Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Marchetti B. L' Episcopo F, et al. Among authors: morale mc. CNS Neurol Disord Drug Targets. 2010 Jul;9(3):349-72. doi: 10.2174/187152710791292639. CNS Neurol Disord Drug Targets. 2010. PMID: 20438439 Review.
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