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High-Throughput Screening of Mouse Gene Knockouts Identifies Established and Novel High Body Fat Phenotypes.
Powell DR, Revelli JP, Doree DD, DaCosta CM, Desai U, Shadoan MK, Rodriguez L, Mullens M, Yang QM, Ding ZM, Kirkpatrick LL, Vogel P, Zambrowicz B, Sands AT, Platt KA, Hansen GM, Brommage R. Powell DR, et al. Diabetes Metab Syndr Obes. 2021 Aug 28;14:3753-3785. doi: 10.2147/DMSO.S322083. eCollection 2021. Diabetes Metab Syndr Obes. 2021. PMID: 34483672 Free PMC article.
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT. Zambrowicz BP, et al. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14. doi: 10.1073/pnas.2336103100. Epub 2003 Nov 10. Proc Natl Acad Sci U S A. 2003. PMID: 14610273 Free PMC article.
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.
Desai U, Lee EC, Chung K, Gao C, Gay J, Key B, Hansen G, Machajewski D, Platt KA, Sands AT, Schneider M, Van Sligtenhorst I, Suwanichkul A, Vogel P, Wilganowski N, Wingert J, Zambrowicz BP, Landes G, Powell DR. Desai U, et al. Among authors: zambrowicz bp. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11766-71. doi: 10.1073/pnas.0705041104. Epub 2007 Jul 3. Proc Natl Acad Sci U S A. 2007. PMID: 17609370 Free PMC article.
High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes.
Brommage R, Desai U, Revelli JP, Donoviel DB, Fontenot GK, Dacosta CM, Smith DD, Kirkpatrick LL, Coker KJ, Donoviel MS, Eberhart DE, Holt KH, Kelly MR, Paradee WJ, Philips AV, Platt KA, Suwanichkul A, Hansen GM, Sands AT, Zambrowicz BP, Powell DR. Brommage R, et al. Among authors: zambrowicz bp. Obesity (Silver Spring). 2008 Oct;16(10):2362-7. doi: 10.1038/oby.2008.361. Epub 2008 Jul 31. Obesity (Silver Spring). 2008. PMID: 18719666 Free article.
High-throughput mouse knockouts provide a functional analysis of the genome.
Friddle CJ, Abuin A, Ramirez-Solis R, Richter LJ, Buxton EC, Edwards J, Finch RA, Gupta A, Hansen G, Holt KH, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Newhouse M, Perry T, Platt KA, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Tran D, Wann ER, Walke W, Wallace JD, Xu N, Zhu Q, Person C, Sands AT, Zambrowicz BP. Friddle CJ, et al. Among authors: zambrowicz bp. Cold Spring Harb Symp Quant Biol. 2003;68:311-5. doi: 10.1101/sqb.2003.68.311. Cold Spring Harb Symp Quant Biol. 2003. PMID: 15338631 No abstract available.
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