Schumacher AM - Search Results

1

An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.

Velentza AV, Wainwright MS, Zasadzki M, Mirzoeva S, Schumacher AM, Haiech J, Focia PJ, Egli M, Watterson DM. Velentza AV, et al. Among authors: schumacher am. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3465-70. doi: 10.1016/s0960-894x(03)00733-9. Bioorg Med Chem Lett. 2003. PMID: 14505650

2

Structure, activity, regulation, and inhibitor discovery for a protein kinase associated with apoptosis and neuronal death.

Velentza AV, Schumacher AM, Watterson DM. Velentza AV, et al. Among authors: schumacher am. Pharmacol Ther. 2002 Feb-Mar;93(2-3):217-24. doi: 10.1016/s0163-7258(02)00190-0. Pharmacol Ther. 2002. PMID: 12191613 Review.

3

Death-associated protein kinase as a potential therapeutic target.

Schumacher AM, Velentza AV, Watterson DM. Schumacher AM, et al. Expert Opin Ther Targets. 2002 Aug;6(4):497-506. doi: 10.1517/14728222.6.4.497. Expert Opin Ther Targets. 2002. PMID: 12223064 Review.

4

DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury.

Schumacher AM, Velentza AV, Watterson DM, Wainwright MS. Schumacher AM, et al. Biochim Biophys Acta. 2002 Nov 4;1600(1-2):128-37. doi: 10.1016/s1570-9639(02)00453-3. Biochim Biophys Acta. 2002. PMID: 12445468

5

A calmodulin-regulated protein kinase linked to neuron survival is a substrate for the calmodulin-regulated death-associated protein kinase.

Schumacher AM, Schavocky JP, Velentza AV, Mirzoeva S, Watterson DM. Schumacher AM, et al. Biochemistry. 2004 Jun 29;43(25):8116-24. doi: 10.1021/bi049589v. Biochemistry. 2004. PMID: 15209507

6

Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis.

Schumacher AM, Velentza AV, Watterson DM, Dresios J. Schumacher AM, et al. Biochemistry. 2006 Nov 14;45(45):13614-21. doi: 10.1021/bi060413y. Biochemistry. 2006. PMID: 17087515 Free PMC article.

7

A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.

Velentza AV, Schumacher AM, Weiss C, Egli M, Watterson DM. Velentza AV, et al. Among authors: schumacher am. J Biol Chem. 2001 Oct 19;276(42):38956-65. doi: 10.1074/jbc.M104273200. Epub 2001 Aug 1. J Biol Chem. 2001. PMID: 11483604 Free article.

8

Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.

Tully DC, Vidal A, Chatterjee AK, Williams JA, Roberts MJ, Petrassi HM, Spraggon G, Bursulaya B, Pacoma R, Shipway A, Schumacher AM, Danahay H, Harris JL. Tully DC, et al. Among authors: schumacher am. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5895-9. doi: 10.1016/j.bmcl.2008.08.029. Epub 2008 Aug 14. Bioorg Med Chem Lett. 2008. PMID: 18752942

9

Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists.

Rooney L, Vidal A, D'Souza AM, Devereux N, Masick B, Boissel V, West R, Head V, Stringer R, Lao J, Petrus MJ, Patapoutian A, Nash M, Stoakley N, Panesar M, Verkuyl JM, Schumacher AM, Petrassi HM, Tully DC. Rooney L, et al. Among authors: schumacher am. J Med Chem. 2014 Jun 26;57(12):5129-40. doi: 10.1021/jm401986p. Epub 2014 Jun 13. J Med Chem. 2014. PMID: 24884675

10

Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.

Liu YA, Jin Q, Zou Y, Ding Q, Yan S, Wang Z, Hao X, Nguyen B, Zhang X, Pan J, Mo T, Jacobsen K, Lam T, Wu TY, Petrassi HM, Bursulaya B, DiDonato M, Gordon WP, Liu B, Baaten J, Hill R, Nguyen-Tran V, Qiu M, Zhang YQ, Kamireddy A, Espinola S, Deaton L, Ha S, Harb G, Jia Y, Li J, Shen W, Schumacher AM, Colman K, Glynne R, Pan S, McNamara P, Laffitte B, Meeusen S, Molteni V, Loren J. Liu YA, et al. Among authors: schumacher am. J Med Chem. 2020 Mar 26;63(6):2958-2973. doi: 10.1021/acs.jmedchem.9b01624. Epub 2020 Feb 20. J Med Chem. 2020. PMID: 32077280

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