HPLC/1H NMR spectroscopic studies of the reactive alpha-1-O-acyl isomer formed during acyl migration of S-naproxen beta-1-O-acyl glucuronide.
Corcoran O, Mortensen RW, Hansen SH, Troke J, Nicholson JK.
Corcoran O, et al.
Chem Res Toxicol. 2001 Oct;14(10):1363-70. doi: 10.1021/tx010015q.
Chem Res Toxicol. 2001.
PMID: 11599927
Moreover, "dynamic" stopped-flow HPLC/1H NMR experiments revealed transacylation of the isolated alpha-1-O-acyl isomer to a mixture of alpha/beta-2-O-acyl isomers; the reverse reaction from the isolated alpha/beta-2-O-acyl isomers to the alpha-1-O-acyl …
Moreover, "dynamic" stopped-flow HPLC/1H NMR experiments revealed transacylation of the isolated alpha-1-O-acyl isomer to a mixture o …