Duffy JL - Search Results

1

HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent.

Duffy JL, Rano TA, Kevin NJ, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2569-72. doi: 10.1016/s0960-894x(03)00475-x. Bioorg Med Chem Lett. 2003. PMID: 12852968

2

Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains.

Duffy JL, Kevin NJ, Kirk BA, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2423-6. doi: 10.1016/s0960-894x(02)00425-0. Bioorg Med Chem Lett. 2002. PMID: 12161148

3

HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent.

Duffy JL, Kirk BA, Kevin NJ, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3323-6. doi: 10.1016/s0960-894x(03)00680-2. Bioorg Med Chem Lett. 2003. PMID: 12951118

4

Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir.

Kevin NJ, Duffy JL, Kirk BA, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Kevin NJ, et al. Among authors: duffy jl. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4027-30. doi: 10.1016/j.bmcl.2003.08.049. Bioorg Med Chem Lett. 2003. PMID: 14592500

5

Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor.

Duffy JL, Kirk BA, Konteatis Z, Campbell EL, Liang R, Brady EJ, Candelore MR, Ding VD, Jiang G, Liu F, Qureshi SA, Saperstein R, Szalkowski D, Tong S, Tota LM, Xie D, Yang X, Zafian P, Zheng S, Chapman KT, Zhang BB, Tata JR. Duffy JL, et al. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1401-5. doi: 10.1016/j.bmcl.2005.01.003. Bioorg Med Chem Lett. 2005. PMID: 15713396

6

Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor.

Cohen SM, Duffy JL, Miller C, Kirk BA, Candelore MR, Ding VD, Kaczorowski G, Tota LM, Werrmann JG, Wright M, Parmee ER, Tata JR, Zhang BB. Cohen SM, et al. Among authors: duffy jl. Bioorg Med Chem. 2006 Mar 1;14(5):1506-17. doi: 10.1016/j.bmc.2005.10.008. Epub 2005 Oct 25. Bioorg Med Chem. 2006. PMID: 16256355

7

A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects.

Qureshi SA, Rios Candelore M, Xie D, Yang X, Tota LM, Ding VD, Li Z, Bansal A, Miller C, Cohen SM, Jiang G, Brady E, Saperstein R, Duffy JL, Tata JR, Chapman KT, Moller DE, Zhang BB. Qureshi SA, et al. Among authors: duffy jl. Diabetes. 2004 Dec;53(12):3267-73. doi: 10.2337/diabetes.53.12.3267. Diabetes. 2004. PMID: 15561959

8

Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.

Edmondson SD, Mastracchio A, Duffy JL, Eiermann GJ, He H, Ita I, Leiting B, Leone JF, Lyons KA, Makarewicz AM, Patel RA, Petrov A, Wu JK, Thornberry NA, Weber AE. Edmondson SD, et al. Among authors: duffy jl. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3048-52. doi: 10.1016/j.bmcl.2005.04.028. Bioorg Med Chem Lett. 2005. PMID: 15908206

9

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.

Duffy JL, Kirk BA, Wang L, Eiermann GJ, He H, Leiting B, Lyons KA, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE. Duffy JL, et al. Bioorg Med Chem Lett. 2007 May 15;17(10):2879-85. doi: 10.1016/j.bmcl.2007.02.066. Epub 2007 Feb 25. Bioorg Med Chem Lett. 2007. PMID: 17350841

10

Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.

Hoyt SB, London C, Ok H, Gonzalez E, Duffy JL, Abbadie C, Dean B, Felix JP, Garcia ML, Jochnowitz N, Karanam BV, Li X, Lyons KA, McGowan E, Macintyre DE, Martin WJ, Priest BT, Smith MM, Tschirret-Guth R, Warren VA, Williams BS, Kaczorowski GJ, Parsons WH. Hoyt SB, et al. Among authors: duffy jl. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6172-7. doi: 10.1016/j.bmcl.2007.09.032. Epub 2007 Sep 11. Bioorg Med Chem Lett. 2007. PMID: 17889534

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