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Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T. Santos RA, et al. Among authors: schultheiss hp. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8258-63. doi: 10.1073/pnas.1432869100. Epub 2003 Jun 26. Proc Natl Acad Sci U S A. 2003. PMID: 12829792 Free PMC article.
The genetic deletion of Mas abolishes salt induced hypertension in mice.
Heringer-Walther S, Gembardt F, Perschel FH, Katz N, Schultheiss HP, Walther T. Heringer-Walther S, et al. Among authors: schultheiss hp. Eur J Pharmacol. 2012 Aug 15;689(1-3):147-53. doi: 10.1016/j.ejphar.2012.05.025. Epub 2012 May 28. Eur J Pharmacol. 2012. PMID: 22652430
Angiotensin deficiency in mice leads to dilated cardiomyopathy.
Walther T, Steendijk P, Westermann D, Hohmann C, Schulze K, Heringer-Walther S, Schultheiss HP, Tschöpe C. Walther T, et al. Among authors: schultheiss hp. Eur J Pharmacol. 2004 Jun 16;493(1-3):161-5. doi: 10.1016/j.ejphar.2004.04.032. Eur J Pharmacol. 2004. PMID: 15189777
591 results