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Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA.
Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF, Adams DJ, Lewis RJ. Sharpe IA, et al. Among authors: chen s. J Biol Chem. 2003 Sep 5;278(36):34451-7. doi: 10.1074/jbc.M305410200. Epub 2003 Jun 24. J Biol Chem. 2003. PMID: 12824165 Free article.
Phe(303) in TMVI of the alpha(1B)-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation.
Chen S, Lin F, Xu M, Graham RM. Chen S, et al. Biochemistry. 2002 Jan 15;41(2):588-96. doi: 10.1021/bi011868k. Biochemistry. 2002. PMID: 11781098
We showed previously that Phe(303) in transmembrane segment (TM) VI of the alpha(1B)-adrenergic receptor, a highly conserved residue in G-protein-coupled receptors (GPCRs), is critically involved in receptor-activation and G-protein-coupling [Chen, S. H., Lin, F., X …
We showed previously that Phe(303) in transmembrane segment (TM) VI of the alpha(1B)-adrenergic receptor, a highly conserved residue in G-pr …
RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation.
Chen S, Lin F, Hamm HE. Chen S, et al. J Biol Chem. 2005 Sep 30;280(39):33445-52. doi: 10.1074/jbc.M505422200. Epub 2005 Jul 28. J Biol Chem. 2005. PMID: 16051595 Free article.
Receptor for Activated C Kinase 1 (RACK1), a novel G betagamma-interacting protein, selectively inhibits the activation of a subclass of G betagamma effectors such as phospholipase C beta2 (PLCbeta2) and adenylyl cyclase II by direct binding to G betagamma (Chen, S. …
Receptor for Activated C Kinase 1 (RACK1), a novel G betagamma-interacting protein, selectively inhibits the activation of a subclass of G b …
81,755 results
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