Murphy MP - Search Results

1

Peptide-based, irreversible inhibitors of gamma-secretase activity.

Piper SC, Amtul Z, Galiñanes-Garcia L, Howard VG, Ziani-Cherif C, McLendon C, Rochette MJ, Fauq A, Golde TE, Murphy MP. Piper SC, et al. Among authors: murphy mp. Biochem Biophys Res Commun. 2003 Jun 6;305(3):529-33. doi: 10.1016/s0006-291x(03)00828-3. Biochem Biophys Res Commun. 2003. PMID: 12763025

2

FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants.

Murphy MP, Uljon SN, Golde TE, Wang R. Murphy MP, et al. Biochim Biophys Acta. 2002 Mar 16;1586(2):199-209. doi: 10.1016/s0925-4439(01)00098-9. Biochim Biophys Acta. 2002. PMID: 11959461 Free article.

3

Overexpression of nicastrin increases Abeta production.

Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE. Murphy MP, et al. FASEB J. 2003 Jun;17(9):1138-40. doi: 10.1096/fj.02-1050fje. Epub 2003 Apr 8. FASEB J. 2003. PMID: 12692078

4

Gamma-secretase: substrates and inhibitors.

Rochette MJ, Murphy MP. Rochette MJ, et al. Among authors: murphy mp. Mol Neurobiol. 2002 Aug;26(1):81-95. doi: 10.1385/MN:26:1:081. Mol Neurobiol. 2002. PMID: 12392058

5

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage.

Murphy MP, Uljon SN, Fraser PE, Fauq A, Lookingbill HA, Findlay KA, Smith TE, Lewis PA, McLendon DC, Wang R, Golde TE. Murphy MP, et al. J Biol Chem. 2000 Aug 25;275(34):26277-84. doi: 10.1074/jbc.M002812200. J Biol Chem. 2000. PMID: 10816583 Free article.

6

Cell-free assays for gamma-secretase activity.

McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. McLendon C, et al. Among authors: murphy mp. FASEB J. 2000 Dec;14(15):2383-6. doi: 10.1096/fj.00-0286fje. FASEB J. 2000. PMID: 11024004

7

An empirical model of gamma-secretase activity.

Murphy MP, Wang R, Fraser PE, Fauq A, Golde TE. Murphy MP, et al. Ann N Y Acad Sci. 2000;920:233-40. doi: 10.1111/j.1749-6632.2000.tb06928.x. Ann N Y Acad Sci. 2000. PMID: 11193156

8

Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.

Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, Murphy MP, Golde TE. Levites Y, et al. Among authors: murphy mp. J Clin Invest. 2006 Jan;116(1):193-201. doi: 10.1172/JCI25410. Epub 2005 Dec 8. J Clin Invest. 2006. PMID: 16341263 Free PMC article.

9

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.

Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE. Kukar T, et al. Among authors: murphy mp. Nat Med. 2005 May;11(5):545-50. doi: 10.1038/nm1235. Epub 2005 Apr 17. Nat Med. 2005. PMID: 15834426

10

Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice.

Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE. Das P, et al. Among authors: murphy mp. J Neurosci. 2003 Sep 17;23(24):8532-8. doi: 10.1523/JNEUROSCI.23-24-08532.2003. J Neurosci. 2003. PMID: 13679422 Free PMC article.

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