Holmes A - Search Results

1

Synthesis and biological evaluation of non-peptidic cyclophilin ligands.

Wu YQ, Belyakov S, Choi C, Limburg D, Thomas IV BE, Vaal M, Wei L, Wilkinson DE, Holmes A, Fuller M, McCormick J, Connolly M, Moeller T, Steiner J, Hamilton GS. Wu YQ, et al. Among authors: holmes a. J Med Chem. 2003 Mar 27;46(7):1112-5. doi: 10.1021/jm020409u. J Med Chem. 2003. PMID: 12646018

2

Synthesis, molecular modeling and biological evaluation of aza-proline and aza-pipecolic derivatives as FKBP12 ligands and their in vivo neuroprotective effects.

Wilkinson DE, Thomas BE 4th, Limburg DC, Holmes A, Sauer H, Ross DT, Soni R, Chen Y, Guo H, Howorth P, Valentine H, Spicer D, Fuller M, Steiner JP, Hamilton GS, Wu YQ. Wilkinson DE, et al. Among authors: holmes a. Bioorg Med Chem. 2003 Nov 3;11(22):4815-25. doi: 10.1016/s0968-0896(03)00478-4. Bioorg Med Chem. 2003. PMID: 14556798

3

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.

Klutchko S, Blankley CJ, Fleming RW, Hinkley JM, Werner AE, Nordin I, Holmes A, Hoefle ML, Cohen DM, Essenburg AD, et al. Klutchko S, et al. Among authors: holmes a. J Med Chem. 1986 Oct;29(10):1953-61. doi: 10.1021/jm00160a026. J Med Chem. 1986. PMID: 3020249

4

Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents.

Trivedi BK, Holmes A, Stoeber TL, Blankley CJ, Roark WH, Picard JA, Shaw MK, Essenburg AD, Stanfield RL, Krause BR. Trivedi BK, et al. Among authors: holmes a. J Med Chem. 1993 Oct 29;36(22):3300-7. doi: 10.1021/jm00074a011. J Med Chem. 1993. PMID: 8230120

5

Second generation "peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile.

Trivedi BK, Padia JK, Holmes A, Rose S, Wright DS, Hinton JP, Pritchard MC, Eden JM, Kneen C, Webdale L, Suman-Chauhan N, Boden P, Singh L, Field MJ, Hill D. Trivedi BK, et al. Among authors: holmes a. J Med Chem. 1998 Jan 1;41(1):38-45. doi: 10.1021/jm970065l. J Med Chem. 1998. PMID: 9438020

6

Inhibitors of acyl-CoA:cholesterol acyltransferase: novel trisubstituted ureas as hypocholesterolemic agents.

Purchase TS, Essenburg AD, Hamelehle KL, Hes MS, Holmes A, Krause BR, Stanfield RL, Trivedi BK. Purchase TS, et al. Among authors: holmes a. Bioorg Med Chem. 1997 Apr;5(4):739-47. doi: 10.1016/s0968-0896(97)00019-9. Bioorg Med Chem. 1997. PMID: 9158873

7

Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogues: potent angiotensin converting enzyme inhibitors.

Meyer RF, Nicolaides ED, Tinney FJ, Lunney EA, Holmes A, Hoefle ML, Smith RD, Essenburg AD, Kaplan HR, Almquist RG. Meyer RF, et al. Among authors: holmes a. J Med Chem. 1981 Aug;24(8):964-9. doi: 10.1021/jm00140a010. J Med Chem. 1981. PMID: 6173481

8

Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond.

Roark WH, Roth BD, Holmes A, Trivedi BK, Kieft KA, Essenburg AD, Krause BR, Stanfield RL. Roark WH, et al. Among authors: holmes a. J Med Chem. 1993 May 28;36(11):1662-8. doi: 10.1021/jm00063a016. J Med Chem. 1993. PMID: 8496932

9

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents.

Roth BD, Blankley CJ, Hoefle ML, Holmes A, Roark WH, Trivedi BK, Essenburg AD, Kieft KA, Krause BR, Stanfield RL. Roth BD, et al. Among authors: holmes a. J Med Chem. 1992 May 1;35(9):1609-17. doi: 10.1021/jm00087a016. J Med Chem. 1992. PMID: 1578488

10

Diuretics. 3-amino- and 3-hydroxy-7-chloro-3,4-dihydro-4-oxo-6-quinazolinesulfonamides.

Hoefle ML, Holmes A. Hoefle ML, et al. Among authors: holmes a. J Med Chem. 1968 Sep;11(5):974-6. doi: 10.1021/jm00311a013. J Med Chem. 1968. PMID: 5697108 No abstract available.

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