St George-Hyslop P - Search Results

1

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.

Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, Fraser P, Westaway D, St George-Hyslop P. Rozmahel R, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14452-7. doi: 10.1073/pnas.222413999. Epub 2002 Oct 18. Proc Natl Acad Sci U S A. 2002. PMID: 12388777 Free PMC article.

2

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH. Sherrington R, et al. Nature. 1995 Jun 29;375(6534):754-60. doi: 10.1038/375754a0. Nature. 1995. PMID: 7596406

3

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.

Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Citron M, et al. Nat Med. 1997 Jan;3(1):67-72. doi: 10.1038/nm0197-67. Nat Med. 1997. PMID: 8986743

4

The clinical phenotype of two missense mutations in the presenilin I gene in Japanese patients.

Ikeda M, Sharma V, Sumi SM, Rogaeva EA, Poorkaj P, Sherrington R, Nee L, Tsuda T, Oda N, Watanabe M, Aoki M, Shoji M, Abe K, Itoyama Y, Hirai S, Schellenberg GD, Bird TD, St George-Hyslop PH. Ikeda M, et al. Ann Neurol. 1996 Dec;40(6):912-7. doi: 10.1002/ana.410400614. Ann Neurol. 1996. PMID: 9007097

5

Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease.

Rogaev EI, Sherrington R, Wu C, Levesque G, Liang Y, Rogaeva EA, Ikeda M, Holman K, Lin C, Lukiw WJ, de Jong PJ, Fraser PE, Rommens JM, St George-Hyslop P. Rogaev EI, et al. Genomics. 1997 Mar 15;40(3):415-24. doi: 10.1006/geno.1996.4523. Genomics. 1997. PMID: 9073509

6

Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.

Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Podlisny MB, et al. Neurobiol Dis. 1997;3(4):325-37. doi: 10.1006/nbdi.1997.0129. Neurobiol Dis. 1997. PMID: 9173929

7

Two homologous genes causing early-onset familial Alzheimer's disease.

St George-Hyslop PH, Levesque G, Levesque L, Rommens J, Westaway D, Fraser PE. St George-Hyslop PH, et al. Cold Spring Harb Symp Quant Biol. 1996;61:559-64. Cold Spring Harb Symp Quant Biol. 1996. PMID: 9246482 No abstract available.

8

Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations.

Okochi M, Ishii K, Usami M, Sahara N, Kametani F, Tanaka K, Fraser PE, Ikeda M, Saunders AM, Hendriks L, Shoji SI, Nee LE, Martin JJ, Van Broeckhoven C, St George-Hyslop PH, Roses AD, Mori H. Okochi M, et al. FEBS Lett. 1997 Nov 24;418(1-2):162-6. doi: 10.1016/s0014-5793(97)01378-1. FEBS Lett. 1997. PMID: 9414118 Free article.

9

Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.

Brindle N, Song Y, Rogaeva E, Premkumar S, Levesque G, Yu G, Ikeda M, Nishimura M, Paterson A, Sorbi S, Duara R, Farrer L, St George-Hyslop P. Brindle N, et al. Hum Mol Genet. 1998 May;7(5):933-5. doi: 10.1093/hmg/7.5.933. Hum Mol Genet. 1998. PMID: 9536099

10

Presenilin 1 is actively degraded by the 26S proteasome.

Fraser PE, Levesque G, Yu G, Mills LR, Thirlwell J, Frantseva M, Gandy SE, Seeger M, Carlen PL, St George-Hyslop P. Fraser PE, et al. Neurobiol Aging. 1998 Jan-Feb;19(1 Suppl):S19-21. doi: 10.1016/s0197-4580(98)00029-3. Neurobiol Aging. 1998. PMID: 9562462 Free article.

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