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Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
J Med Chem. 2002 Aug 29;45(18):3905-27. doi: 10.1021/jm0201520.
J Med Chem. 2002.
PMID: 12190313
N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.
Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ, Qian L, Chen BC, Zhao R, Bednarz MS, Kellar KA, Mulheron JG, Batorsky R, Roongta U, Kamath A, Marathe P, Ranadive SA, Sack JS, Tokarski JS, Pavletich NP, Lee FY, Webster KR, Kimball SD.
Misra RN, et al. Among authors: roongta u.
J Med Chem. 2004 Mar 25;47(7):1719-28. doi: 10.1021/jm0305568.
J Med Chem. 2004.
PMID: 15027863
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Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent.
Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ, Qian L, Chen BC, Zhao R, Bednarz MS, Kellar KA, Mulheron JG, Batorsky R, Roongta U, Kamath A, Marathe P, Ranadive SA, Sack JS, Tokarski JS, Pavletich NP, Lee FY, Webster KR, Kimball SD.
Misra RN, et al. Among authors: roongta u.
J Med Chem. 2015 Sep 24;58(18):7609. doi: 10.1021/acs.jmedchem.5b01294. Epub 2015 Sep 2.
J Med Chem. 2015.
PMID: 26328598
No abstract available.
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Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy.
Roongta UV, Pabalan JG, Wang X, Ryseck RP, Fargnoli J, Henley BJ, Yang WP, Zhu J, Madireddi MT, Lawrence RM, Wong TW, Rupnow BA.
Roongta UV, et al.
Mol Cancer Res. 2011 Nov;9(11):1551-61. doi: 10.1158/1541-7786.MCR-11-0126. Epub 2011 Sep 27.
Mol Cancer Res. 2011.
PMID: 21954435
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Induction of fibroblast apoptosis by anti-CD44 antibody: implications for the treatment of fibroproliferative lung disease.
Henke C, Bitterman P, Roongta U, Ingbar D, Polunovsky V.
Henke C, et al. Among authors: roongta u.
Am J Pathol. 1996 Nov;149(5):1639-50.
Am J Pathol. 1996.
PMID: 8909253
Free PMC article.
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Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44.
Svee K, White J, Vaillant P, Jessurun J, Roongta U, Krumwiede M, Johnson D, Henke C.
Svee K, et al. Among authors: roongta u.
J Clin Invest. 1996 Oct 15;98(8):1713-27. doi: 10.1172/JCI118970.
J Clin Invest. 1996.
PMID: 8878421
Free PMC article.
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CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix.
Henke CA, Roongta U, Mickelson DJ, Knutson JR, McCarthy JB.
Henke CA, et al. Among authors: roongta u.
J Clin Invest. 1996 Jun 1;97(11):2541-52. doi: 10.1172/JCI118702.
J Clin Invest. 1996.
PMID: 8647947
Free PMC article.
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