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ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.
Cancer Res. 2002 Aug 15;62(16):4645-55.
Cancer Res. 2002.
PMID: 12183421
Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy.
Curwen JO, Musgrove HL, Kendrew J, Richmond GH, Ogilvie DJ, Wedge SR.
Curwen JO, et al. Among authors: musgrove hl.
Clin Cancer Res. 2008 May 15;14(10):3124-31. doi: 10.1158/1078-0432.CCR-07-4783.
Clin Cancer Res. 2008.
PMID: 18483380
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The contribution of VEGF signalling to fostamatinib-induced blood pressure elevation.
Skinner M, Philp K, Lengel D, Coverley L, Lamm Bergström E, Glaves P, Musgrove H, Prior H, Braddock M, Huby R, Curwen JO, Duffy P, Harmer AR.
Skinner M, et al.
Br J Pharmacol. 2014 May;171(9):2308-20. doi: 10.1111/bph.12559.
Br J Pharmacol. 2014.
PMID: 24329544
Free PMC article.
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Prevention of fostamatinib-induced blood pressure elevation by antihypertensive agents.
Lengel D, Lamm Bergström E, Barthlow H, Oldman K, Musgrove H, Harmer A, Valentin JP, Duffy P, Braddock M, Curwen J.
Lengel D, et al.
Pharmacol Res Perspect. 2015 Oct;3(5):e00176. doi: 10.1002/prp2.176. Epub 2015 Sep 15.
Pharmacol Res Perspect. 2015.
PMID: 26516588
Free PMC article.
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Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.
McCoull W, Boyd S, Brown MR, Coen M, Collingwood O, Davies NL, Doherty A, Fairley G, Goldberg K, Hardaker E, He G, Hennessy EJ, Hopcroft P, Hodgson G, Jackson A, Jiang X, Karmokar A, Lainé AL, Lindsay N, Mao Y, Markandu R, McMurray L, McLean N, Mooney L, Musgrove H, Nissink JWM, Pflug A, Reddy VP, Rawlins PB, Rivers E, Schimpl M, Smith GF, Tentarelli S, Travers J, Troup RI, Walton J, Wang C, Wilkinson S, Williamson B, Winter-Holt J, Yang D, Zheng Y, Zhu Q, Smith PD.
McCoull W, et al.
J Med Chem. 2021 Sep 23;64(18):13524-13539. doi: 10.1021/acs.jmedchem.1c00920. Epub 2021 Sep 3.
J Med Chem. 2021.
PMID: 34478292
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Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models.
Aherne GW, Ward E, Lawrence N, Dobinson D, Clarke SJ, Musgrove H, Sutcliffe F, Stephens T, Jackman AL.
Aherne GW, et al.
Br J Cancer. 1998;77(2):221-6. doi: 10.1038/bjc.1998.37.
Br J Cancer. 1998.
PMID: 9460992
Free PMC article.
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