Palin R - Search Results

1

Novel piperidinium and pyridinium agents as water-soluble acetylcholinesterase inhibitors for the reversal of neuromuscular blockade.

Palin R, Clark JK, Cowley P, Muir AW, Pow E, Prosser AB, Taylor R, Zhang MQ. Palin R, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2569-72. doi: 10.1016/s0960-894x(02)00483-3. Bioorg Med Chem Lett. 2002. PMID: 12182862

2

Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships.

Adam JM, Bennett DJ, Bom A, Clark JK, Feilden H, Hutchinson EJ, Palin R, Prosser A, Rees DC, Rosair GM, Stevenson D, Tarver GJ, Zhang MQ. Adam JM, et al. Among authors: palin r. J Med Chem. 2002 Apr 25;45(9):1806-16. doi: 10.1021/jm011107f. J Med Chem. 2002. PMID: 11960492

3

Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.

Clark JK, Cowley P, Muir AW, Palin R, Pow E, Prosser AB, Taylor R, Zhang MQ. Clark JK, et al. Among authors: palin r. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2565-8. doi: 10.1016/s0960-894x(02)00482-1. Bioorg Med Chem Lett. 2002. PMID: 12182861

4

New approaches to reversal of neuromuscular block.

Bom A, Clark JK, Palin R. Bom A, et al. Among authors: palin r. Curr Opin Drug Discov Devel. 2002 Sep;5(5):793-800. Curr Opin Drug Discov Devel. 2002. PMID: 12630300 Review.

5

A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host.

Bom A, Bradley M, Cameron K, Clark JK, Van Egmond J, Feilden H, MacLean EJ, Muir AW, Palin R, Rees DC, Zhang MQ. Bom A, et al. Among authors: palin r. Angew Chem Int Ed Engl. 2002 Jan 18;41(2):266-70. doi: 10.1002/1521-3773(20020118)41:2<265::aid-anie265>3.0.co;2-q. Angew Chem Int Ed Engl. 2002. PMID: 12491405 No abstract available.

6

Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists.

Palin R, Barn DR, Clark JK, Cottney JE, Cowley PM, Crockatt M, Evans L, Feilden H, Goodwin RR, Griekspoor F, Grove SJ, Houghton AK, Jones PS, Morphy RJ, Smith AR, Sundaram H, Vrolijk D, Weston MA, Wishart G, Wren P. Palin R, et al. Bioorg Med Chem Lett. 2005 Feb 1;15(3):589-93. doi: 10.1016/j.bmcl.2004.11.049. Bioorg Med Chem Lett. 2005. PMID: 15664818

7

Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties.

Palin R, Bom A, Clark JK, Evans L, Feilden H, Houghton AK, Jones PS, Montgomery B, Weston MA, Wishart G. Palin R, et al. Bioorg Med Chem. 2007 Feb 15;15(4):1828-47. doi: 10.1016/j.bmc.2006.11.030. Epub 2006 Nov 19. Bioorg Med Chem. 2007. PMID: 17166723

8

Structure-activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties.

Palin R, Clark JK, Evans L, Houghton AK, Jones PS, Prosser A, Wishart G, Yoshiizumi K. Palin R, et al. Bioorg Med Chem. 2008 Mar 15;16(6):2829-51. doi: 10.1016/j.bmc.2008.01.005. Epub 2008 Jan 10. Bioorg Med Chem. 2008. PMID: 18249547

9

Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.

Palin R, Clark JK, Evans L, Feilden H, Fletcher D, Hamilton NM, Houghton AK, Jones PS, McArthur D, Montgomery B, Ratcliffe PD, Smith AR, Sutherland A, Weston MA, Wishart G. Palin R, et al. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6441-6. doi: 10.1016/j.bmcl.2009.09.028. Epub 2009 Sep 12. Bioorg Med Chem Lett. 2009. PMID: 19818611

10

The discovery of novel indole-2-carboxamides as cannabinoid CB(1) receptor antagonists.

Cowley PM, Baker J, Barn DR, Buchanan KI, Carlyle I, Clark JK, Clarkson TR, Deehan M, Edwards D, Goodwin RR, Jaap D, Kiyoi Y, Mort C, Palin R, Prosser A, Walker G, Ward N, Wishart G, Young T. Cowley PM, et al. Among authors: palin r. Bioorg Med Chem Lett. 2011 Jan 1;21(1):497-501. doi: 10.1016/j.bmcl.2010.10.104. Epub 2010 Oct 26. Bioorg Med Chem Lett. 2011. PMID: 21075628

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