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4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships.
Pirotte B, Podona T, Diouf O, de Tullio P, Lebrun P, Dupont L, Somers F, Delarge J, Morain P, Lestage P, Lepagnol J, Spedding M. Pirotte B, et al. Among authors: lestage p. J Med Chem. 1998 Jul 30;41(16):2946-59. doi: 10.1021/jm970694v. J Med Chem. 1998. PMID: 9685234
The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis.
Millan MJ, Gobert A, Roux S, Porsolt R, Meneses A, Carli M, Di Cara B, Jaffard R, Rivet JM, Lestage P, Mocaer E, Peglion JL, Dekeyne A. Millan MJ, et al. Among authors: lestage p. J Pharmacol Exp Ther. 2004 Oct;311(1):190-203. doi: 10.1124/jpet.104.069625. Epub 2004 May 14. J Pharmacol Exp Ther. 2004. PMID: 15146031
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