Hughes G - Search Results

1

Prevention of mitochondrial oxidative damage using targeted antioxidants.

Kelso GF, Porteous CM, Hughes G, Ledgerwood EC, Gane AM, Smith RA, Murphy MP. Kelso GF, et al. Among authors: hughes g. Ann N Y Acad Sci. 2002 Apr;959:263-74. doi: 10.1111/j.1749-6632.2002.tb02098.x. Ann N Y Acad Sci. 2002. PMID: 11976201

2

Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach.

Lin TK, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar V, Smith RA, Murphy MP. Lin TK, et al. Among authors: hughes g. J Biol Chem. 2002 May 10;277(19):17048-56. doi: 10.1074/jbc.M110797200. Epub 2002 Feb 22. J Biol Chem. 2002. PMID: 11861642 Free article.

3

Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants.

Hughes G, Murphy MP, Ledgerwood EC. Hughes G, et al. Biochem J. 2005 Jul 1;389(Pt 1):83-9. doi: 10.1042/BJ20050078. Biochem J. 2005. PMID: 15727562 Free PMC article.

4

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties.

Kelso GF, Porteous CM, Coulter CV, Hughes G, Porteous WK, Ledgerwood EC, Smith RA, Murphy MP. Kelso GF, et al. Among authors: hughes g. J Biol Chem. 2001 Feb 16;276(7):4588-96. doi: 10.1074/jbc.M009093200. Epub 2000 Nov 22. J Biol Chem. 2001. PMID: 11092892 Free article.

5

Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences.

Smith RA, Kelso GF, Blaikie FH, Porteous CM, Ledgerwood EC, Hughes G, James AM, Ross MF, Asin-Cayuela J, Cochemé HM, Filipovska A, Murphy MP. Smith RA, et al. Among authors: hughes g. Biochem Soc Trans. 2003 Dec;31(Pt 6):1295-9. doi: 10.1042/bst0311295. Biochem Soc Trans. 2003. PMID: 14641046

6

Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis.

Cox AG, Pullar JM, Hughes G, Ledgerwood EC, Hampton MB. Cox AG, et al. Among authors: hughes g. Free Radic Biol Med. 2008 Mar 15;44(6):1001-9. doi: 10.1016/j.freeradbiomed.2007.11.017. Epub 2007 Dec 5. Free Radic Biol Med. 2008. PMID: 18164270

7

Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells.

Scarlett JL, Sheard PW, Hughes G, Ledgerwood EC, Ku HH, Murphy MP. Scarlett JL, et al. Among authors: hughes g. FEBS Lett. 2000 Jun 23;475(3):267-72. doi: 10.1016/s0014-5793(00)01681-1. FEBS Lett. 2000. PMID: 10869569 Free article.

8

Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA.

Appleby RD, Porteous WK, Hughes G, James AM, Shannon D, Wei YH, Murphy MP. Appleby RD, et al. Among authors: hughes g. Eur J Biochem. 1999 May;262(1):108-16. doi: 10.1046/j.1432-1327.1999.00350.x. Eur J Biochem. 1999. PMID: 10231371 Free article.

9

Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination.

Josephs TM, Liptak MD, Hughes G, Lo A, Smith RM, Wilbanks SM, Bren KL, Ledgerwood EC. Josephs TM, et al. Among authors: hughes g. J Biol Inorg Chem. 2013 Mar;18(3):289-97. doi: 10.1007/s00775-012-0973-1. Epub 2013 Jan 19. J Biol Inorg Chem. 2013. PMID: 23334161 Free PMC article.

10

A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.

Morison IM, Cramer Bordé EM, Cheesman EJ, Cheong PL, Holyoake AJ, Fichelson S, Weeks RJ, Lo A, Davies SM, Wilbanks SM, Fagerlund RD, Ludgate MW, da Silva Tatley FM, Coker MS, Bockett NA, Hughes G, Pippig DA, Smith MP, Capron C, Ledgerwood EC. Morison IM, et al. Among authors: hughes g. Nat Genet. 2008 Apr;40(4):387-9. doi: 10.1038/ng.103. Epub 2008 Mar 16. Nat Genet. 2008. PMID: 18345000

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