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Beta(1)-selective agonist (-)-1-(3,4-dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(-)-RO363] differentially interacts with key amino acids responsible for beta(1)-selective binding in resting and active states.
Sugimoto Y, Fujisawa R, Tanimura R, Lattion AL, Cotecchia S, Tsujimoto G, Nagao T, Kurose H. Sugimoto Y, et al. Among authors: tanimura r. J Pharmacol Exp Ther. 2002 Apr;301(1):51-8. doi: 10.1124/jpet.301.1.51. J Pharmacol Exp Ther. 2002. PMID: 11907156
Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.
Nagumo Y, Katoh K, Iio K, Saitoh T, Kutsumura N, Yamamoto N, Ishikawa Y, Irukayama-Tomobe Y, Ogawa Y, Baba T, Tanimura R, Yanagisawa M, Nagase H. Nagumo Y, et al. Among authors: tanimura r. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127360. doi: 10.1016/j.bmcl.2020.127360. Epub 2020 Jun 19. Bioorg Med Chem Lett. 2020. PMID: 32738987
Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.
Iio K, Saitoh T, Ohshita R, Hino T, Amezawa M, Takayama Y, Nagumo Y, Yamamoto N, Kutsumura N, Irukayama-Tomobe Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H. Iio K, et al. Among authors: tanimura r. Bioorg Med Chem Lett. 2022 Mar 15;60:128555. doi: 10.1016/j.bmcl.2022.128555. Epub 2022 Jan 17. Bioorg Med Chem Lett. 2022. PMID: 35051577
Determinants of protein side-chain packing.
Tanimura R, Kidera A, Nakamura H. Tanimura R, et al. Protein Sci. 1994 Dec;3(12):2358-65. doi: 10.1002/pro.5560031220. Protein Sci. 1994. PMID: 7756990 Free PMC article.
44 results