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TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.
Baillie GS, Huston E, Scotland G, Hodgkin M, Gall I, Peden AH, MacKenzie C, Houslay ES, Currie R, Pettitt TR, Walmsley AR, Wakelam MJ, Warwicker J, Houslay MD. Baillie GS, et al. Among authors: houslay md, houslay es. J Biol Chem. 2002 Aug 2;277(31):28298-309. doi: 10.1074/jbc.M108353200. Epub 2002 May 6. J Biol Chem. 2002. PMID: 11994273 Free article.
Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.
Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung YF, Campbell L, Millen JE, Smith RA, Gall I, Knowles RG, Sullivan M, Houslay MD. Wallace DA, et al. Among authors: houslay tm, houslay md. Mol Pharmacol. 2005 Jun;67(6):1920-34. doi: 10.1124/mol.104.009423. Epub 2005 Feb 28. Mol Pharmacol. 2005. PMID: 15738310
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD. McCahill A, et al. Among authors: houslay md. Cell Signal. 2005 Sep;17(9):1158-73. doi: 10.1016/j.cellsig.2005.04.003. Cell Signal. 2005. PMID: 15905070
Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.
Sheppard CL, Lee LC, Hill EV, Henderson DJ, Anthony DF, Houslay DM, Yalla KC, Cairns LS, Dunlop AJ, Baillie GS, Huston E, Houslay MD. Sheppard CL, et al. Among authors: houslay dm, houslay md. Cell Signal. 2014 Sep;26(9):1958-74. doi: 10.1016/j.cellsig.2014.04.023. Epub 2014 May 9. Cell Signal. 2014. PMID: 24815749
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Houslay MD, Scotland G, Erdogan S, Huston E, Mackenzie S, McCallum JF, McPhee I, Pooley L, Rena G, Ross A, Beard M, Peder A, Begg F, Wilkinson I, Yarwood S, Ackerman C, Houslay ES, Hoffman R, Engels P, Sullivan M, Bolger G. Houslay MD, et al. Among authors: houslay es. Biochem Soc Trans. 1997 May;25(2):374-81. doi: 10.1042/bst0250374. Biochem Soc Trans. 1997. PMID: 9191121 Review. No abstract available.
413 results