Issafras H - Search Results

1

Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies.

Blanpain C, Vanderwinden JM, Cihak J, Wittamer V, Le Poul E, Issafras H, Stangassinger M, Vassart G, Marullo S, Schlndorff D, Parmentier M, Mack M. Blanpain C, et al. Among authors: issafras h. Mol Biol Cell. 2002 Feb;13(2):723-37. doi: 10.1091/mbc.01-03-0129. Mol Biol Cell. 2002. PMID: 11854425 Free PMC article.

2

Constitutive agonist-independent CCR5 oligomerization and antibody-mediated clustering occurring at physiological levels of receptors.

Issafras H, Angers S, Bulenger S, Blanpain C, Parmentier M, Labbé-Jullié C, Bouvier M, Marullo S. Issafras H, et al. J Biol Chem. 2002 Sep 20;277(38):34666-73. doi: 10.1074/jbc.M202386200. Epub 2002 Jun 27. J Biol Chem. 2002. PMID: 12089144 Free article.

3

Homo- and hetero-oligomerization of beta-arrestins in living cells.

Storez H, Scott MG, Issafras H, Burtey A, Benmerah A, Muntaner O, Piolot T, Tramier M, Coppey-Moisan M, Bouvier M, Labbé-Jullié C, Marullo S. Storez H, et al. Among authors: issafras h. J Biol Chem. 2005 Dec 2;280(48):40210-5. doi: 10.1074/jbc.M508001200. Epub 2005 Sep 30. J Biol Chem. 2005. PMID: 16199535 Free article.

4

The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.

Shore DA, Issafras H, Landais E, Teyton L, Wilson IA. Shore DA, et al. Among authors: issafras h. J Mol Biol. 2008 Dec 31;384(5):1190-202. doi: 10.1016/j.jmb.2008.09.069. Epub 2008 Oct 7. J Mol Biol. 2008. PMID: 18929574 Free PMC article.

5

Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.

Roell MK, Issafras H, Bauer RJ, Michelson KS, Mendoza N, Vanegas SI, Gross LM, Larsen PD, Bedinger DH, Bohmann DJ, Nonet GH, Liu N, Lee SR, Handa M, Kantak SS, Horwitz AH, Hunter JJ, Owyang AM, Mirza AM, Corbin JA, White ML. Roell MK, et al. Among authors: issafras h. J Biol Chem. 2010 Jul 2;285(27):20607-14. doi: 10.1074/jbc.M110.115790. Epub 2010 Apr 21. J Biol Chem. 2010. PMID: 20410301 Free PMC article.

6

Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties.

Issafras H, Corbin JA, Goldfine ID, Roell MK. Issafras H, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):202-15. doi: 10.1124/jpet.113.205443. Epub 2013 Nov 5. J Pharmacol Exp Ther. 2014. PMID: 24194526 Free PMC article.

7

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice.

Bhaskar V, Yin J, Mirza AM, Phan D, Vanegas S, Issafras H, Michelson K, Hunter JJ, Kantak SS. Bhaskar V, et al. Among authors: issafras h. Atherosclerosis. 2011 Jun;216(2):313-20. doi: 10.1016/j.atherosclerosis.2011.02.026. Epub 2011 Feb 24. Atherosclerosis. 2011. PMID: 21411094

8

Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.

Corbin JA, Bhaskar V, Goldfine ID, Issafras H, Bedinger DH, Lau A, Michelson K, Gross LM, Maddux BA, Kuan HF, Tran C, Lao L, Handa M, Watson SR, Narasimha AJ, Zhu S, Levy R, Webster L, Wijesuriya SD, Liu N, Wu X, Chemla-Vogel D, Lee SR, Wong S, Wilcock D, Rubin P, White ML. Corbin JA, et al. Among authors: issafras h. MAbs. 2014 Jan-Feb;6(1):262-72. doi: 10.4161/mabs.26871. MAbs. 2014. PMID: 24423625 Free PMC article.

9

Selective allosteric antibodies to the insulin receptor for the treatment of hyperglycemic and hypoglycemic disorders.

Issafras H, Bedinger DH, Corbin JA, Goldfine ID, Bhaskar V, White ML, Rubin P, Scannon PJ. Issafras H, et al. J Diabetes Sci Technol. 2014 Jul;8(4):865-73. doi: 10.1177/1932296814529886. Epub 2014 Apr 7. J Diabetes Sci Technol. 2014. PMID: 24876415 Free PMC article.

10

Enhancement of antibody fragment secretion into the Escherichia coli periplasm by co-expression with the peptidyl prolyl isomerase, FkpA, in the cytoplasm.

Levy R, Ahluwalia K, Bohmann DJ, Giang HM, Schwimmer LJ, Issafras H, Reddy NB, Chan C, Horwitz AH, Takeuchi T. Levy R, et al. Among authors: issafras h. J Immunol Methods. 2013 Aug 30;394(1-2):10-21. doi: 10.1016/j.jim.2013.04.010. Epub 2013 Apr 23. J Immunol Methods. 2013. PMID: 23624043 Free article.

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