Jonckers T - Search Results

1

Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-[2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone.

Singh SP, Ansari WH, Lemière G, Jonckers T, Dommisse R. Singh SP, et al. Among authors: jonckers t. Eur J Med Chem. 2002 Jan;37(1):63-7. doi: 10.1016/s0223-5234(01)01268-5. Eur J Med Chem. 2002. PMID: 11841875

2

Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.

Jonckers TH, van Miert S, Cimanga K, Bailly C, Colson P, De Pauw-Gillet MC, van den Heuvel H, Claeys M, Lemière F, Esmans EL, Rozenski J, Quirijnen L, Maes L, Dommisse R, Lemière GL, Vlietinck A, Pieters L. Jonckers TH, et al. J Med Chem. 2002 Aug 1;45(16):3497-508. doi: 10.1021/jm011102i. J Med Chem. 2002. PMID: 12139461

3

In vitro inhibition of beta-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivatives.

Van Miert S, Jonckers T, Cimanga K, Maes L, Maes B, Lemière G, Dommisse R, Vlietinck A, Pieters L. Van Miert S, et al. Among authors: jonckers t. Exp Parasitol. 2004 Nov-Dec;108(3-4):163-8. doi: 10.1016/j.exppara.2004.08.006. Exp Parasitol. 2004. PMID: 15582513

4

Design, synthesis, and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids.

D'hooghe M, Mollet K, De Vreese R, Jonckers TH, Dams G, De Kimpe N. D'hooghe M, et al. J Med Chem. 2012 Jun 14;55(11):5637-41. doi: 10.1021/jm300383k. Epub 2012 May 17. J Med Chem. 2012. PMID: 22519297

5

2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.

Jonckers TH, Lin TI, Buyck C, Lachau-Durand S, Vandyck K, Van Hoof S, Vandekerckhove LA, Hu L, Berke JM, Vijgen L, Dillen LL, Cummings MD, de Kock H, Nilsson M, Sund C, Rydegård C, Samuelsson B, Rosenquist A, Fanning G, Van Emelen K, Simmen K, Raboisson P. Jonckers TH, et al. J Med Chem. 2010 Nov 25;53(22):8150-60. doi: 10.1021/jm101050a. Epub 2010 Oct 29. J Med Chem. 2010. PMID: 21033671

6

Differentiation between isomeric phenylglycidyl ether adducts of 2'-deoxyguanosine and 2'-deoxyguanosine-5'-monophosphate using liquid chromatography/electrospray tandem mass spectrometry.

Lemière F, Vanhoutte K, Jonckers T, Marek R, Esmans EL, Claeys M, Van den Eeckhout E, Van Onckelen H. Lemière F, et al. Among authors: jonckers t. J Mass Spectrom. 1999 Aug;34(8):820-34. doi: 10.1002/(SICI)1096-9888(199908)34:8<820::AID-JMS837>3.0.CO;2-C. J Mass Spectrom. 1999. PMID: 10423563

7

Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.

Surleraux DL, Tahri A, Verschueren WG, Pille GM, de Kock HA, Jonckers TH, Peeters A, De Meyer S, Azijn H, Pauwels R, de Bethune MP, King NM, Prabu-Jeyabalan M, Schiffer CA, Wigerinck PB. Surleraux DL, et al. Among authors: jonckers th. J Med Chem. 2005 Mar 24;48(6):1813-22. doi: 10.1021/jm049560p. J Med Chem. 2005. PMID: 15771427

8

Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.

Jonckers TH, Vandyck K, Vandekerckhove L, Hu L, Tahri A, Van Hoof S, Lin TI, Vijgen L, Berke JM, Lachau-Durand S, Stoops B, Leclercq L, Fanning G, Samuelsson B, Nilsson M, Rosenquist Å, Simmen K, Raboisson P. Jonckers TH, et al. J Med Chem. 2014 Mar 13;57(5):1836-44. doi: 10.1021/jm4015422. Epub 2014 Jan 6. J Med Chem. 2014. PMID: 24345201

9

Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.

Jonckers TH, Tahri A, Vijgen L, Berke JM, Lachau-Durand S, Stoops B, Snoeys J, Leclercq L, Tambuyzer L, Lin TI, Simmen K, Raboisson P. Jonckers TH, et al. J Med Chem. 2016 Jun 23;59(12):5790-8. doi: 10.1021/acs.jmedchem.6b00382. Epub 2016 Jun 3. J Med Chem. 2016. PMID: 27181575

10

Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus.

Vendeville S, Tahri A, Hu L, Demin S, Cooymans L, Vos A, Kwanten L, Van den Berg J, Battles MB, McLellan JS, Koul A, Raboisson P, Roymans D, Jonckers THM. Vendeville S, et al. Among authors: jonckers thm. J Med Chem. 2020 Aug 13;63(15):8046-8058. doi: 10.1021/acs.jmedchem.0c00226. Epub 2020 Jun 15. J Med Chem. 2020. PMID: 32407115

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