Van Eldik LJ - Search Results

1

Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound.

Mirzoeva S, Sawkar A, Zasadzki M, Guo L, Velentza AV, Dunlap V, Bourguignon JJ, Ramstrom H, Haiech J, Van Eldik LJ, Watterson DM. Mirzoeva S, et al. Among authors: van eldik lj. J Med Chem. 2002 Jan 31;45(3):563-6. doi: 10.1021/jm015573g. J Med Chem. 2002. PMID: 11806708

2

Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses.

Watterson DM, Haiech J, Van Eldik LJ. Watterson DM, et al. Among authors: van eldik lj. J Mol Neurosci. 2002 Aug-Oct;19(1-2):89-93. doi: 10.1007/s12031-002-0016-4. J Mol Neurosci. 2002. PMID: 12212800

3

Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's disease progression.

Watterson DM, Velentza AV, Zasadzki M, Craft JM, Haiech J, Van Eldik LJ. Watterson DM, et al. Among authors: van eldik lj. J Mol Neurosci. 2003;20(3):411-23. doi: 10.1385/JMN:20:3:411. J Mol Neurosci. 2003. PMID: 14501026

4

Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.

Watterson DM, Mirzoeva S, Guo L, Whyte A, Bourguignon JJ, Hibert M, Haiech J, Van Eldik LJ. Watterson DM, et al. Among authors: van eldik lj. Neurochem Int. 2001 Nov-Dec;39(5-6):459-68. doi: 10.1016/s0197-0186(01)00053-5. Neurochem Int. 2001. PMID: 11578781

5

Neuroinflammation: a potential therapeutic target.

Craft JM, Watterson DM, Van Eldik LJ. Craft JM, et al. Among authors: van eldik lj. Expert Opin Ther Targets. 2005 Oct;9(5):887-900. doi: 10.1517/14728222.9.5.887. Expert Opin Ther Targets. 2005. PMID: 16185146 Review.

6

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

Hu W, Ralay Ranaivo H, Roy SM, Behanna HA, Wing LK, Munoz L, Guo L, Van Eldik LJ, Watterson DM. Hu W, et al. Among authors: van eldik lj. Bioorg Med Chem Lett. 2007 Jan 15;17(2):414-8. doi: 10.1016/j.bmcl.2006.10.028. Epub 2006 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 17079143 Free PMC article.

7

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

Roy SM, Minasov G, Arancio O, Chico LW, Van Eldik LJ, Anderson WF, Pelletier JC, Watterson DM. Roy SM, et al. Among authors: van eldik lj. J Med Chem. 2019 Jun 13;62(11):5298-5311. doi: 10.1021/acs.jmedchem.9b00058. Epub 2019 Apr 23. J Med Chem. 2019. PMID: 30978288 Free PMC article. Review.

8

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation.

Craft JM, Van Eldik LJ, Zasadzki M, Hu W, Watterson DM. Craft JM, et al. Among authors: van eldik lj. J Mol Neurosci. 2004;24(1):115-22. doi: 10.1385/JMN:24:1:115. J Mol Neurosci. 2004. PMID: 15314259

9

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

Ralay Ranaivo H, Craft JM, Hu W, Guo L, Wing LK, Van Eldik LJ, Watterson DM. Ralay Ranaivo H, et al. Among authors: van eldik lj. J Neurosci. 2006 Jan 11;26(2):662-70. doi: 10.1523/JNEUROSCI.4652-05.2006. J Neurosci. 2006. PMID: 16407564 Free PMC article.

10

The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.

Borders AS, de Almeida L, Van Eldik LJ, Watterson DM. Borders AS, et al. Among authors: van eldik lj. BMC Neurosci. 2008 Dec 3;9 Suppl 2(Suppl 2):S12. doi: 10.1186/1471-2202-9-S2-S12. BMC Neurosci. 2008. PMID: 19090985 Free PMC article. Review.

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