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The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation.
Penninger JM, Fischer KD, Sasaki T, Kozieradzki I, Le J, Tedford K, Bachmaier K, Ohashi PS, Bachmann MF. Penninger JM, et al. Among authors: bachmaier k. Eur J Immunol. 1999 May;29(5):1709-18. doi: 10.1002/(SICI)1521-4141(199905)29:05<1709::AID-IMMU1709>3.0.CO;2-O. Eur J Immunol. 1999. PMID: 10359126 Free article.
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.
Sasaki T, Irie-Sasaki J, Horie Y, Bachmaier K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S, Khokha R, Mak TW, Hawkins PT, Stephens L, Scherer SW, Tsao M, Penninger JM. Sasaki T, et al. Among authors: bachmaier k. Nature. 2000 Aug 24;406(6798):897-902. doi: 10.1038/35022585. Nature. 2000. PMID: 10972292
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