Laine B - Search Results

1

Functional study of the E276Q mutant hepatocyte nuclear factor-4alpha found in type 1 maturity-onset diabetes of the young: impaired synergy with chicken ovalbumin upstream promoter transcription factor II on the hepatocyte nuclear factor-1 promoter.

Suaud L, Hemimou Y, Formstecher P, Laine B. Suaud L, et al. Among authors: laine b. Diabetes. 1999 May;48(5):1162-7. doi: 10.2337/diabetes.48.5.1162. Diabetes. 1999. PMID: 10331424

2

Mutations in hepatocyte nuclear factor 4alpha (HNF4alpha) gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells.

Oxombre B, Moerman E, Eeckhoute J, Formstecher P, Laine B. Oxombre B, et al. Among authors: laine b. J Mol Med (Berl). 2002 Jul;80(7):423-30. doi: 10.1007/s00109-002-0340-8. Epub 2002 May 8. J Mol Med (Berl). 2002. PMID: 12110948

3

The G115S mutation associated with maturity-onset diabetes of the young impairs hepatocyte nuclear factor 4alpha activities and introduces a PKA phosphorylation site in its DNA-binding domain.

Oxombre B, Kouach M, Moerman E, Formstecher P, Laine B. Oxombre B, et al. Among authors: laine b. Biochem J. 2004 Nov 1;383(Pt. 3):573-80. doi: 10.1042/BJ20040473. Biochem J. 2004. PMID: 15233628 Free PMC article.

4

A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.

Hani EH, Suaud L, Boutin P, Chèvre JC, Durand E, Philippi A, Demenais F, Vionnet N, Furuta H, Velho G, Bell GI, Laine B, Froguel P. Hani EH, et al. Among authors: laine b. J Clin Invest. 1998 Feb 1;101(3):521-6. doi: 10.1172/JCI1403. J Clin Invest. 1998. PMID: 9449683 Free PMC article.

5

The activity of the activation function 2 of the human hepatocyte nuclear factor 4 (HNF-4alpha) is differently modulated by F domains from various origins.

Suaud L, Formstecher P, Laine B. Suaud L, et al. Among authors: laine b. Biochem J. 1999 May 15;340 ( Pt 1)(Pt 1):161-9. Biochem J. 1999. PMID: 10229671 Free PMC article.

6

Functional properties of the R154X HNF-4alpha protein generated by a mutation associated with maturity-onset diabetes of the young, type 1.

Laine B, Eeckhoute J, Suaud L, Briche I, Furuta H, Bell GI, Formstecher P. Laine B, et al. FEBS Lett. 2000 Aug 11;479(1-2):41-5. doi: 10.1016/s0014-5793(00)01864-0. FEBS Lett. 2000. PMID: 10940385 Free article.

7

Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator.

Eeckhoute J, Formstecher P, Laine B. Eeckhoute J, et al. Among authors: laine b. Mol Endocrinol. 2001 Jul;15(7):1200-10. doi: 10.1210/mend.15.7.0670. Mol Endocrinol. 2001. PMID: 11435618

8

Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms.

Eeckhoute J, Moerman E, Bouckenooghe T, Lukoviak B, Pattou F, Formstecher P, Kerr-Conte J, Vandewalle B, Laine B. Eeckhoute J, et al. Among authors: laine b. Endocrinology. 2003 May;144(5):1686-94. doi: 10.1210/en.2002-0024. Endocrinology. 2003. PMID: 12697672

9

Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription.

Eeckhoute J, Formstecher P, Laine B. Eeckhoute J, et al. Among authors: laine b. Nucleic Acids Res. 2004 May 11;32(8):2586-93. doi: 10.1093/nar/gkh581. Print 2004. Nucleic Acids Res. 2004. PMID: 15141028 Free PMC article.

10

Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1.

Eeckhoute J, Briche I, Kurowska M, Formstecher P, Laine B. Eeckhoute J, et al. Among authors: laine b. J Mol Biol. 2006 Dec 8;364(4):567-81. doi: 10.1016/j.jmb.2006.07.096. Epub 2006 Sep 12. J Mol Biol. 2006. PMID: 17022998

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