Synthesis and antituberculosis activity of new 2-quinoxalinecarbonitrile 1,4-di-N-oxides

M A Ortega; Y Sainz; M E Montoya; A López De Ceráin; A Monge

Synthesis and antituberculosis activity of new 2-quinoxalinecarbonitrile 1,4-di-N-oxides

Pharmazie. 1999 Jan;54(1):24-5.

Authors

M A Ortega¹, Y Sainz, M E Montoya, A López De Ceráin, A Monge

Affiliation

¹ Centro de Investigación en Farmacobiología Aplicada, Universidad de Navarra, España.

PMID: 9987794

Abstract

With the advent of multidrug-resistant Mycobacterium tuberculosis strains, new and effective therapies are rapidly needed to combat infections caused by these strains. Some new 2-quinoxalinecarbonitrile 1,4-di-N-oxides have been synthesized and tested as antituberculosis agents and interesting results have been obtained from the first screening.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis*
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Quinoxalines / chemical synthesis*
Quinoxalines / chemistry
Quinoxalines / pharmacology
Rifampin / pharmacology
Spectrophotometry, Infrared
Structure-Activity Relationship

Substances

Antitubercular Agents
Quinoxalines
Rifampin