Organometallic flavonoid derivatives as spectroscopic probes

C E Anson; C S Creaser; J A Downie; O Egyed; A V Malkov; L Mojovic; G R Stephenson; A T Turner; K E Wilson

doi:10.1016/s0960-894x(98)00638-6

Organometallic flavonoid derivatives as spectroscopic probes

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3549-54. doi: 10.1016/s0960-894x(98)00638-6.

Authors

C E Anson¹, C S Creaser, J A Downie, O Egyed, A V Malkov, L Mojovic, G R Stephenson, A T Turner, K E Wilson

Affiliation

¹ School of Chemical Sciences, University of East Anglia, Norwich, UK.

PMID: 9934469
DOI: 10.1016/s0960-894x(98)00638-6

Abstract

Derivatives of naringenin have been synthesized with organometalcarbonyl reporting groups for IR spectroscopy attached at C-2, C-3', or C-6, and the products have been tested for the induction of nod gene expression using a Rhizobium leguminosarum strain which contains the Escherichia coli lacZ (beta-galactosidase) gene fused to nodABC. Derivatives with an OMe substituent within the reporting group moiety showed residual gene induction activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Escherichia coli / genetics
Flavonoids / chemistry*
Flavonoids / pharmacology
Gene Expression Regulation, Bacterial / drug effects
Lac Operon
Lipopolysaccharides / metabolism
Molecular Probes
Rhizobium leguminosarum / enzymology
Rhizobium leguminosarum / genetics
Spectroscopy, Fourier Transform Infrared
Transcriptional Activation

Substances

Flavonoids
Lipopolysaccharides
Molecular Probes
Nod factor, Rhizobium leguminosarum