Is an intravenous bolus injection required prior to initiating slow intravenous infusion of PACAP38 for prevention of neuronal death induced by global ischemia? The possible presence of a binding protein for PACAP38 in blood

Ann N Y Acad Sci. 1998 Dec 11:865:595-600. doi: 10.1111/j.1749-6632.1998.tb11243.x.

Authors

A Somogyvári-Vigh¹, J Svoboda-Teet, S Vigh, A Arimura

Affiliation

¹ Department of Medicine, Tulane University, School of Medicine, New Orleans, Louisiana 70112, USA.

PMID: 9928076
DOI: 10.1111/j.1749-6632.1998.tb11243.x

No abstract available

MeSH terms

Adenylyl Cyclases / metabolism
Animals
Carrier Proteins / blood*
Cell Death / drug effects
Cells, Cultured
Cyclic AMP / metabolism
Drug Administration Schedule
Humans
Infusions, Intravenous
Injections, Intravenous
Ischemic Attack, Transient / pathology*
Ischemic Attack, Transient / physiopathology
Neurons / drug effects
Neurons / pathology*
Neuropeptides / administration & dosage
Neuropeptides / blood*
Neuropeptides / pharmacology*
Neuroprotective Agents / administration & dosage
Neuroprotective Agents / blood
Neuroprotective Agents / pharmacology*
Pituitary Adenylate Cyclase-Activating Polypeptide
Pituitary Gland / drug effects
Pituitary Gland / physiology
Posture
Prosencephalon / pathology
Prosencephalon / physiopathology
Rabbits
Rats

Substances

ADCYAP1 protein, human
Adcyap1 protein, rat
Carrier Proteins
Neuropeptides
Neuroprotective Agents
Pituitary Adenylate Cyclase-Activating Polypeptide
Cyclic AMP
Adenylyl Cyclases