Abstract
In this paper, we report on the conformational analysis of several polyether triterpenes with a squalene carbon skeleton which exhibited significant cytotoxic activity using a Monte Carlo conformational search and spectroscopical data. These studies indicate that the conformation of the side chain C-14/C-19 and the arrangement and direction of this chain may be among the fundamental factors related to the activity of this type of metabolites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Survival / drug effects*
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Chromatography, High Pressure Liquid
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Colonic Neoplasms
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Ethers / chemistry
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Ethers / isolation & purification
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Ethers / toxicity*
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Humans
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Leukemia P388
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Lung Neoplasms
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Melanoma
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Mice
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Seaweed*
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Squalene / chemistry
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Squalene / isolation & purification
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Squalene / toxicity
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Structure-Activity Relationship
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / toxicity*
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Tumor Cells, Cultured
Substances
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Ethers
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Triterpenes
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Squalene