Evaluation of the cytotoxic activity of polyethers isolated from Laurencia

Bioorg Med Chem. 1998 Dec;6(12):2237-43. doi: 10.1016/s0968-0896(98)80004-7.

Abstract

In this paper, we report on the conformational analysis of several polyether triterpenes with a squalene carbon skeleton which exhibited significant cytotoxic activity using a Monte Carlo conformational search and spectroscopical data. These studies indicate that the conformation of the side chain C-14/C-19 and the arrangement and direction of this chain may be among the fundamental factors related to the activity of this type of metabolites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / drug effects*
  • Chromatography, High Pressure Liquid
  • Colonic Neoplasms
  • Ethers / chemistry
  • Ethers / isolation & purification
  • Ethers / toxicity*
  • Humans
  • Leukemia P388
  • Lung Neoplasms
  • Melanoma
  • Mice
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Seaweed*
  • Squalene / chemistry
  • Squalene / isolation & purification
  • Squalene / toxicity
  • Structure-Activity Relationship
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / toxicity*
  • Tumor Cells, Cultured

Substances

  • Ethers
  • Triterpenes
  • Squalene