5-Arylidene-3-aryl-pyrrolidine-2,4-diones with affinity to the N-methyl-D-aspartate (glycine site) receptor, Part I

Arch Pharm (Weinheim). 1998 Dec;331(12):389-94. doi: 10.1002/(sici)1521-4184(199812)331:12<389::aid-ardp389>3.0.co;2-w.

Abstract

A series of new 5-arylidene 3-aryl-pyrrolidine-2,4-diones has been prepared. Their binding affinity toward the N-methyl-D-aspartate (glycine site) receptor has been measured as a basis for more detailed structure-activity relationship studies.

MeSH terms

  • Binding Sites
  • Binding, Competitive
  • Indoles / metabolism
  • Infrared Rays
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Molecular Structure
  • Protein Binding
  • Pyrrolidinones / chemical synthesis*
  • Receptors, N-Methyl-D-Aspartate / metabolism*
  • Structure-Activity Relationship

Substances

  • Indoles
  • MDL 105519
  • Pyrrolidinones
  • Receptors, N-Methyl-D-Aspartate