An expeditious procedure for the isolation of ingenol from the seeds of euphorbia lathyris

G Appendino; GC Tron; G Cravotto; G Palmisano; J Jakupovic

doi:10.1021/np980218n

An expeditious procedure for the isolation of ingenol from the seeds of euphorbia lathyris

J Nat Prod. 1999 Jan;62(1):76-9. doi: 10.1021/np980218n.

Authors

G Appendino¹, GC Tron, G Cravotto, G Palmisano, J Jakupovic

Affiliation

¹ Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, and Institut fur Organische Chemie, Technische Universitat Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany.

PMID: 9917286
DOI: 10.1021/np980218n

Abstract

A short and practical process for the isolation of ingenol (1a) from an agricultural commodity (the seeds of Euphorbia lathyris) is described. Macrocyclic diterpene esters are obtained as byproducts, and the esterification pattern of the Euphorbia factors L2 (3), L3 (4a), and L8 (4b) was established by 2D NMR measurements. Full spectroscopic data for these compounds are reported.