Linker histones: paradigm lost but questions remain

S Belikov; V Karpov

doi:10.1016/s0014-5793(98)01512-9

Linker histones: paradigm lost but questions remain

FEBS Lett. 1998 Dec 18;441(2):161-4. doi: 10.1016/s0014-5793(98)01512-9.

Authors

S Belikov¹, V Karpov

Affiliation

¹ Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden. sergey.belikov@cmb.ki.se

PMID: 9883876
DOI: 10.1016/s0014-5793(98)01512-9

Abstract

Linker histones (LH) represent a diverse family of proteins that bind to nucleosomes and bring them together to form a 30-nm chromatin fiber. Although the structure of the globular domain of linker histones H1 and H5 has been solved, the details of its interaction with the nucleosome are not understood in full. Recent data on the location of LH in nucleosome are discussed here.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Binding Sites
DNA-Binding Proteins / chemistry
DNA-Binding Proteins / metabolism
Histones / chemistry
Histones / metabolism*
Models, Molecular
Protein Conformation

Substances

DNA-Binding Proteins
Histones