Alternative solvent-free preparation methods for felodipine surface solid dispersions

Drug Dev Ind Pharm. 1998 Apr;24(4):359-63. doi: 10.3109/03639049809085631.

Abstract

Surface solid dispersions were prepared via physical mixture and were either heated in a vacuum dryer or in a microwave oven for different periods of time. The physical state of felodipine in solid dispersions was studied using differential scanning calorimetry and x-ray powder diffractometry. USP paddle method was used for felodipine dissolution studies. The use of vacuum or microwave energy led to a significant improvement of felodipine dissolution which was caused partly by the amorphous state of felodipine and a large surface area of amorphous silicon dioxide.

Publication types

  • Comparative Study

MeSH terms

  • Calcium Channel Blockers / administration & dosage
  • Calcium Channel Blockers / chemistry
  • Calcium Channel Blockers / isolation & purification*
  • Calorimetry, Differential Scanning
  • Drug Compounding / methods
  • Felodipine / administration & dosage
  • Felodipine / chemistry
  • Felodipine / isolation & purification*
  • Humans
  • Particle Size
  • Solubility
  • Solvents
  • Surface Properties
  • X-Ray Diffraction

Substances

  • Calcium Channel Blockers
  • Solvents
  • Felodipine