Synthesis of diacylamines and the preparation of alpha-amino-acylureas, a new type of alpha-amino acid derivatives

I Weisz; J Roboz; I Wolf; J Szabo; J G Bekesi

doi:10.1016/s0960-894x(98)00593-9

Synthesis of diacylamines and the preparation of alpha-amino-acylureas, a new type of alpha-amino acid derivatives

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3241-4. doi: 10.1016/s0960-894x(98)00593-9.

Authors

I Weisz¹, J Roboz, I Wolf, J Szabo, J G Bekesi

Affiliation

¹ Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

PMID: 9873710
DOI: 10.1016/s0960-894x(98)00593-9

Abstract

Sixteen new and one known unsymmetrical open-chain diacylamines were synthesized by sodium methoxide catalyzed acylation of amides with carboxylic esters and acylamino-carboxylic esters, or acylureas with acylamino-carboxylic esters and alpha-amino acid esters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemical synthesis*
Amino Acids / chemical synthesis*
Anticonvulsants / pharmacology
Antineoplastic Agents / pharmacology

Substances

Amines
Amino Acids
Anticonvulsants
Antineoplastic Agents