Abstract
A complexation study was carried out with okadaic acid (OA) and the univalent metal ions Li+, Na+ and K+, and the divalent metal ions Ca2+ and Mg2+. K+ binding was observed identical with a complex obtained from the natural source (OAC). The pharmacological trials demonstrated that this cation has a very important influence on the pharmacological activity of okadaic acid.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Calcium / chemistry
-
Cations, Divalent / chemistry*
-
Cations, Monovalent / chemistry*
-
Kinetics
-
Lithium / chemistry
-
Magnesium / chemistry
-
Magnetic Resonance Spectroscopy
-
Models, Molecular
-
Molecular Conformation
-
Molecular Structure
-
Okadaic Acid / chemistry*
-
Okadaic Acid / pharmacology
-
Potassium / chemistry
-
Sodium / chemistry
Substances
-
Cations, Divalent
-
Cations, Monovalent
-
Okadaic Acid
-
Lithium
-
Sodium
-
Magnesium
-
Potassium
-
Calcium