Complexation of okadaic acid: a preliminary study

Bioorg Med Chem Lett. 1998 May 5;8(9):1007-12. doi: 10.1016/s0960-894x(98)00152-8.

Abstract

A complexation study was carried out with okadaic acid (OA) and the univalent metal ions Li+, Na+ and K+, and the divalent metal ions Ca2+ and Mg2+. K+ binding was observed identical with a complex obtained from the natural source (OAC). The pharmacological trials demonstrated that this cation has a very important influence on the pharmacological activity of okadaic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / chemistry
  • Cations, Divalent / chemistry*
  • Cations, Monovalent / chemistry*
  • Kinetics
  • Lithium / chemistry
  • Magnesium / chemistry
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Okadaic Acid / chemistry*
  • Okadaic Acid / pharmacology
  • Potassium / chemistry
  • Sodium / chemistry

Substances

  • Cations, Divalent
  • Cations, Monovalent
  • Okadaic Acid
  • Lithium
  • Sodium
  • Magnesium
  • Potassium
  • Calcium