Objective: To investigate the effect of treatment of cachexia with Umbellatus Polyporus Polysaccharide (UPP).
Methods: UPP was used to treat cachexia induced by toxohormone-L.
Results: Toxohormone-L from ascites fluid with primary hepatoma could induce lipolysis in vitro significantly, inhibit the intake behavior, decrease the level of blood zinc, increase that of blood copper (P < 0.01), upp could inhibit these effects.
Conclusion: Toxohormone-L was closely related with neoplastic cachexia and UPP could inhibit this effect induced by toxohormone-L significantly.