[Inhibitive effect of umbellatus polyporus polysaccharide on cachexic manifestation induced by toxohormone-L in rats]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Apr;17(4):232-3.
[Article in Chinese]

Abstract

Objective: To investigate the effect of treatment of cachexia with Umbellatus Polyporus Polysaccharide (UPP).

Methods: UPP was used to treat cachexia induced by toxohormone-L.

Results: Toxohormone-L from ascites fluid with primary hepatoma could induce lipolysis in vitro significantly, inhibit the intake behavior, decrease the level of blood zinc, increase that of blood copper (P < 0.01), upp could inhibit these effects.

Conclusion: Toxohormone-L was closely related with neoplastic cachexia and UPP could inhibit this effect induced by toxohormone-L significantly.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Cachexia / blood
  • Cachexia / chemically induced
  • Cachexia / drug therapy*
  • Copper / blood
  • Endotoxins
  • Lipolysis / drug effects
  • Male
  • Neoplasm Proteins
  • Polyporaceae* / chemistry
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Rats
  • Rats, Wistar
  • Zinc / blood

Substances

  • Blood Glucose
  • Endotoxins
  • Neoplasm Proteins
  • Polysaccharides
  • Copper
  • toxohormone
  • Zinc