The leader sequence of the Escherichia coli lysC gene is involved in the regulation of LysC synthesis

FEMS Microbiol Lett. 1998 Dec 1;169(1):165-70. doi: 10.1111/j.1574-6968.1998.tb13313.x.

Abstract

In Escherichia coli and Bacillus subtilis, long leader sequences are found upstream of the lysC coding sequences which encode lysine-sensitive aspartokinase. Highly conserved regions exist between these sequences. Mutations leading to constitutive expression of the E. coli lysC gene have been localised within these conserved regions, indicating that they participate in the lysine-mediated repression mechanism of lysC expression.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspartate Kinase / biosynthesis
  • Aspartate Kinase / genetics*
  • Base Sequence
  • Escherichia coli / enzymology
  • Escherichia coli / genetics*
  • Gene Expression Regulation, Bacterial
  • Genes, Bacterial
  • Molecular Sequence Data
  • Regulatory Sequences, Nucleic Acid*
  • Sequence Homology, Nucleic Acid

Substances

  • lysC aspartokinase
  • Aspartate Kinase