[Vasoactive properties of various fragments of human alpha-calcitonin gene-related peptide]

V A Akopian; N V Balashov; S V Burov; G P Vlasov

[Vasoactive properties of various fragments of human alpha-calcitonin gene-related peptide]

Ross Fiziol Zh Im I M Sechenova. 1998 Jul;84(7):663-71.

[Article in Russian]

Authors

V A Akopian¹, N V Balashov, S V Burov, G P Vlasov

Affiliation

¹ I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Acad. Sci., St. Petersburg, Russia.

PMID: 9805778

Abstract

Effects of some fragments of alpha-calcitonine gene-related peptide (alpha-CGRP) on the collector lymphatic vessels of the rat small intestine mesenterium, were studied. All the fragments excepting alpha-CGRP (21-24) and (21-31) activate motility of the lymphatic vessels enhancing phasic contractions of the walls. Presence of aminoacid residuals in the 20-29 area is "critical" for realising vasoactive properties by these fragments.

MeSH terms

Animals
Calcitonin Gene-Related Peptide / chemistry
Calcitonin Gene-Related Peptide / physiology*
Humans
In Vitro Techniques
Intestine, Small / drug effects
Lymphatic System / drug effects*
Lymphatic System / physiology
Male
Mesentery / drug effects
Peptide Fragments / chemistry
Peptide Fragments / pharmacology*
Rats
Rats, Wistar
Vasoconstriction / drug effects*

Substances

Peptide Fragments
Calcitonin Gene-Related Peptide