This article introduces a special section on the measurement of stress in occupational and work environments. It discusses stress as a creatively ambiguous term that, nonetheless, has important medical, behavioral, and psychological health consequences for people at work as well as away from work. The article discusses the importance of multiple medical and psychological measures for occupational stress assessments and offers an abbreviated conceptual framework for such measures. The 5 articles and 1 commentary that compose the section are briefly introduced.