Abstract
Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of this trait may contribute to susceptibility to NMS.
MeSH terms
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Alleles
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Amino Acid Substitution
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Antipsychotic Agents / adverse effects*
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Antipsychotic Agents / pharmacokinetics
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Cytochrome P-450 CYP2D6 / genetics*
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Cytochrome P-450 CYP2D6 / physiology
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DNA Mutational Analysis
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Genetic Predisposition to Disease
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Homozygote
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Humans
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Inactivation, Metabolic / genetics
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Male
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Microsomes, Liver / enzymology
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Middle Aged
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Neuroleptic Malignant Syndrome / enzymology
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Neuroleptic Malignant Syndrome / genetics*
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Point Mutation
Substances
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Antipsychotic Agents
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Cytochrome P-450 CYP2D6