Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome

J Neurol Sci. 1998 Sep 18;160(1):102-4. doi: 10.1016/s0022-510x(98)00238-x.

Abstract

Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of this trait may contribute to susceptibility to NMS.

Publication types

  • Case Reports

MeSH terms

  • Alleles
  • Amino Acid Substitution
  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / pharmacokinetics
  • Cytochrome P-450 CYP2D6 / genetics*
  • Cytochrome P-450 CYP2D6 / physiology
  • DNA Mutational Analysis
  • Genetic Predisposition to Disease
  • Homozygote
  • Humans
  • Inactivation, Metabolic / genetics
  • Male
  • Microsomes, Liver / enzymology
  • Middle Aged
  • Neuroleptic Malignant Syndrome / enzymology
  • Neuroleptic Malignant Syndrome / genetics*
  • Point Mutation

Substances

  • Antipsychotic Agents
  • Cytochrome P-450 CYP2D6