Approximately 5% of the general population develops a skin infection each year, leading to a significant number of outpatient visits to the primary care physician. Bacteria, infestations, fungi, yeasts, and viruses are organisms that present with a myriad of cutaneous findings that pose a challenge to the investigating clinician. This article provides a contemporary review of these skin infections, with particular emphasis on clinical features, and a concise, updated review on therapies.