Abstract
Studies with human neonatal rotaviruses RV-3 and S12/85 and their reassortants showed that VP4 is a determinant of rotavirus attachment to and growth in Caco-2 cells. The binding of these viruses to MA104 and Caco-2 cells correlated with their growth ability. Virus sensitivity to trypsin and the VP4 fusion region may be implicated in these processes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Caco-2 Cells
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Capsid / genetics
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Capsid / physiology*
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Capsid Proteins*
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Cell Line
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Genes, Viral
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Humans
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Infant, Newborn
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Molecular Sequence Data
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Rotavirus / genetics
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Rotavirus / growth & development*
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Rotavirus / pathogenicity*
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Rotavirus Infections / etiology
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Rotavirus Infections / virology
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Sequence Homology, Amino Acid
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Trypsin / pharmacology
Substances
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Capsid Proteins
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VP4 protein, Rotavirus
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Trypsin
Associated data
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GENBANK/AF076925
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GENBANK/AF076926