Glycosidopyrroles. Part 3. Effect of the benzocondensation on acyclic derivatives: 1-(2-hydroxyethoxy) methylindoles as potential antiviral agents

Farmaco. 1998 Jun 30;53(6):409-14. doi: 10.1016/s0014-827x(98)00042-1.

Abstract

The new of 1-(2-hydroxyethoxy)methylindole derivatives 3a-i were prepared in good yields. None of them showed any significant anti-HIV activity and therefore the benzocondensation between the 2 and 3 positions of the pyrrole ring definitely reduced the weak activity found in the analogues 1a-c.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / pharmacology
  • Cell Line
  • Chlorocebus aethiops
  • Cytopathogenic Effect, Viral / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • HIV-1 / drug effects
  • HIV-1 / pathogenicity
  • Humans
  • Indoles / chemistry*
  • Microbial Sensitivity Tests
  • Pyrroles / chemistry*
  • Pyrroles / pharmacology
  • Vero Cells
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • Indoles
  • Pyrroles