[A study of correlation between essential hypertension and HLA-DQA1 alleles]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Oct 10;15(5):288-90.
[Article in Chinese]

Abstract

Objective: To analyse the hereditary susceptibility by genotyping of HLA-DQA1 alleles in essential hypertensives.

Methods: The allelic types of HLA-DQA1 were detected by PCR-SSP technic in 52 cases of essential hypertensives and 86 normal individuals as the control.

Results: The frequency of HLA-DQA1*0302 allele in hypertensive group was markedly higher than that in normal control group (17.9572 vs 3.5531), but the frequency of HLA-DQA1*0103 allele in normal group was higher than that in hypertensive group.

Conclusion: HLA-DQA1*0302 may be a correlative gene of essential hypertension, whereas HLA-DQA1*0103 may be a defence gene of hypertension.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Female
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • HLA-DQ Antigens / genetics*
  • HLA-DQ alpha-Chains
  • Humans
  • Hypertension / genetics*
  • Male
  • Middle Aged

Substances

  • HLA-DQ Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQA1 antigen