Abstract
The novel melampolides (11R)-11,13-dihydro-schkuhriolide (7), (11S)-11,13-dihydro-schkuhriolide (8), and schkuhrioidiol (11), along with the known constituents, frutescin (1), schkuhriolide (2), frutescinic acid (4), allo-schkuhriolide (5), and epoxyschkuhriolide (6) were isolated from the aerial parts of Schkuhria schkuhrioides. The structures of the new compounds were determined by spectroscopic methods. Compounds 1, 2, 4, 5, and 6 displayed no significant cytotoxic or antimicrobial activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Artemia
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Humans
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Lactones / isolation & purification
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Lactones / pharmacology*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Plant Leaves / chemistry*
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Plants, Medicinal / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
Substances
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Anti-Infective Agents
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Antineoplastic Agents, Phytogenic
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Lactones
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Sesquiterpenes