Synthesis, structure, and biological activities of some N-(4,5-dihydro-1H-imidazol-2-yl)-1,3-dihydrobenzimidazole derivatives

Arch Pharm (Weinheim). 1998 Jul-Aug;331(7-8):241-8. doi: 10.1002/(sici)1521-4184(199807)331:7/8<241::aid-ardp241>3.0.co;2-6.

Abstract

A series of novel N-(4,5-dihydroimidazol-2-yl)-1,3-dihydrobenzimidazole derivatives 2a-d, 3a-d and 4a-p were prepared and their structure was determined by IR and NMR spectroscopic data as well as X-ray analysis of carbonitrile 2a. The compounds were studied as potential inhibitors of the human blood platelet aggregation induced by adrenaline or ADP. Compounds of type 3 proved efficacious for the reduction of arterial blood pressure upon intravenous administration to normotensive rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzimidazoles / chemical synthesis
  • Benzimidazoles / chemistry*
  • Benzimidazoles / pharmacology
  • Blood Pressure / drug effects
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Heart Rate / drug effects
  • Humans
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Male
  • Platelet Aggregation Inhibitors / chemical synthesis
  • Platelet Aggregation Inhibitors / chemistry*
  • Platelet Aggregation Inhibitors / pharmacology
  • Rats

Substances

  • Benzimidazoles
  • Platelet Aggregation Inhibitors