(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa

J Med Chem. 1998 Sep 10;41(19):3551-6. doi: 10.1021/jm980281+.

Authors

K J Shaw¹, W J Guilford, J L Dallas, S K Koovakkaat, M A McCarrick, A Liang, D R Light, M M Morrissey

Affiliation

¹ Discovery Research, Berlex Biosciences, 15049 San Pablo Avenue, P.O. Box 4099, Richmond, California 94804-0099, USA.

PMID: 9733479
DOI: 10.1021/jm980281+

No abstract available

MeSH terms

Amidines / chemistry*
Amidines / metabolism
Amidines / pharmacology
Amidines / radiation effects
Animals
Benzylidene Compounds / chemistry*
Benzylidene Compounds / metabolism
Benzylidene Compounds / pharmacology
Benzylidene Compounds / radiation effects
Binding Sites
Cattle
Factor Xa Inhibitors*
Humans
Models, Molecular
Molecular Conformation / radiation effects
Photochemistry
Serine Proteinase Inhibitors / chemistry*
Serine Proteinase Inhibitors / metabolism
Serine Proteinase Inhibitors / pharmacology
Serine Proteinase Inhibitors / radiation effects
Stereoisomerism
Thrombin / antagonists & inhibitors
Trypsin Inhibitors / chemistry
Trypsin Inhibitors / metabolism
Trypsin Inhibitors / pharmacology
Trypsin Inhibitors / radiation effects

Substances

Amidines
Benzylidene Compounds
Factor Xa Inhibitors
Serine Proteinase Inhibitors
Trypsin Inhibitors
ZK 805412
Thrombin