Abstract
Human erythrocytes were exposed at room temperatures to 662 keV gamma radiation at doses up to 60 Gy. The total delta Li+ influx as well as the delta Li+ influx by passive diffusion and Na(+)-K+ pump mechanisms increased linearly with the dose. The rate constant K of Li+ efflux by the Li(+)-Na+ countertransport mechanism through irradiated erythrocyte membranes was reduced by about 35% at the highest dose.
MeSH terms
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Cell Membrane / drug effects
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Cell Membrane / metabolism*
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Cell Membrane / radiation effects*
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Dose-Response Relationship, Radiation
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Erythrocytes / drug effects
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Erythrocytes / metabolism*
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Erythrocytes / radiation effects*
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Gamma Rays*
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Humans
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Lithium / pharmacokinetics*
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Ouabain / pharmacology
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Sodium-Potassium-Exchanging ATPase / drug effects
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Sodium-Potassium-Exchanging ATPase / metabolism
Substances
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Ouabain
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Lithium
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Sodium-Potassium-Exchanging ATPase