The effect of gamma radiation on Li+ transport through human erythrocyte membranes

Cytobios. 1998;93(372):23-31.

Abstract

Human erythrocytes were exposed at room temperatures to 662 keV gamma radiation at doses up to 60 Gy. The total delta Li+ influx as well as the delta Li+ influx by passive diffusion and Na(+)-K+ pump mechanisms increased linearly with the dose. The rate constant K of Li+ efflux by the Li(+)-Na+ countertransport mechanism through irradiated erythrocyte membranes was reduced by about 35% at the highest dose.

MeSH terms

  • Cell Membrane / drug effects
  • Cell Membrane / metabolism*
  • Cell Membrane / radiation effects*
  • Dose-Response Relationship, Radiation
  • Erythrocytes / drug effects
  • Erythrocytes / metabolism*
  • Erythrocytes / radiation effects*
  • Gamma Rays*
  • Humans
  • Lithium / pharmacokinetics*
  • Ouabain / pharmacology
  • Sodium-Potassium-Exchanging ATPase / drug effects
  • Sodium-Potassium-Exchanging ATPase / metabolism

Substances

  • Ouabain
  • Lithium
  • Sodium-Potassium-Exchanging ATPase