Abstract
EPR experiments confirm that reaction of qinghaosu and some related endoperoxides with Fe2+ in aqueous acetonitrile leads to the production of carbon-centred radicals derived by rapid rearrangement of first-formed cyclic alkoxyl radicals. Signals obtained from qinghaosu itself with spin-traps DMPO and DBNBS are assigned to the adducts (15) and (16), a finding which accounts for the formation of the major products (11) and (14).
MeSH terms
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Antimalarials / metabolism*
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Antimalarials / pharmacology
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Artemisia / chemistry
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Artemisinins*
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Catalysis
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Drugs, Chinese Herbal / metabolism*
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Drugs, Chinese Herbal / pharmacology
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Electron Spin Resonance Spectroscopy / methods
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Electron Transport
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Ferric Compounds / chemistry*
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Free Radicals / metabolism*
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Iron / metabolism*
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Plants, Medicinal
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Polycyclic Compounds / pharmacology
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Reducing Agents / chemistry
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Sesquiterpenes / metabolism*
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Sesquiterpenes / pharmacology
Substances
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Antimalarials
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Artemisinins
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Drugs, Chinese Herbal
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Ferric Compounds
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Free Radicals
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Polycyclic Compounds
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Reducing Agents
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Sesquiterpenes
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artemisinin
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Iron